Cajun Chicken Alfredo

Featured in: Simple Comfort Foods

This Cajun Chicken Alfredo combines seasoned chicken breasts with a silky cream sauce infused with garlic and Parmesan, tossed with al dente pasta for an impressive yet approachable main course.

Start by cooking fettuccine, then sear Cajun-seasoned chicken until golden. Create the Alfredo sauce by melting butter, sautéing garlic, and gently simmering heavy cream with cheese and seasonings. Combine everything for a restaurant-quality dish that brings Southern spice to Italian comfort food.

Updated on Sun, 18 Jan 2026 16:13:00 GMT
Creamy Cajun Chicken Alfredo served over fettuccine, topped with fresh parsley and extra Parmesan for a flavorful dinner. Save
Creamy Cajun Chicken Alfredo served over fettuccine, topped with fresh parsley and extra Parmesan for a flavorful dinner. | tastyhrira.com

My neighbor knocked on my door one Thursday evening holding a half-empty jar of Cajun seasoning and asked if I knew what to do with it. An hour later, we were standing over my stove watching chicken sizzle in the pan, the smell sharp and smoky enough to make us both hungry before we'd even started the cream. That night turned into this recipe, a dish that somehow makes you feel like you're breaking the rules in the best way possible. The heat from the spice and the cool richness of the Alfredo shouldn't work together, but they do, and it's become the meal I make when I want dinner to feel like an occasion without any fuss. I've never looked at plain chicken the same way since.

I made this for my brother's birthday last spring, and he ate two full plates before admitting he'd told everyone he wasn't that hungry. There's something about the way the creamy sauce clings to the pasta and the chicken that makes it impossible to stop at one serving. My sister-in-law kept asking what the secret was, and I had to admit there wasn't one, just good timing and a willingness to let the garlic get really fragrant before adding the cream. By the end of the night, three people had taken photos of their plates, which felt like the kind of compliment you can't fake.

Ingredients

  • Boneless, skinless chicken breasts: I always pat them dry before seasoning because it helps the Cajun spices stick and creates a better sear in the pan.
  • Cajun seasoning: This is where all the magic lives, a blend of paprika, garlic, pepper, and heat that transforms plain chicken into something you want to talk about.
  • Olive oil: Just enough to coat the pan and keep the chicken from sticking while it develops that golden crust.
  • Fettuccine or linguine: Wide noodles hold onto the sauce better than thin ones, and they make every bite feel more luxurious.
  • Unsalted butter: It lets you control the salt level in the sauce and adds a silky richness that olive oil alone can't achieve.
  • Garlic: Fresh cloves minced fine release their flavor quickly and fill your kitchen with the kind of smell that makes everyone wander in asking when dinner will be ready.
  • Heavy cream: This is the backbone of the Alfredo, thick and rich enough to coat everything without feeling greasy.
  • Parmesan cheese: Freshly grated melts smoothly into the sauce and has a sharpness that balances the cream perfectly.
  • Black pepper and salt: Simple seasonings that let the other flavors shine without competing for attention.
  • Red pepper flakes: Optional, but I always add them because a little extra heat never hurt anyone who loves bold food.
  • Fresh parsley: A handful chopped fine adds color and a hint of freshness that cuts through all that richness at the end.

Instructions

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Cook the pasta:
Bring a large pot of salted water to a rolling boil and add the fettuccine, stirring once to keep it from clumping. Cook it until it's just tender with a slight bite, then save half a cup of the starchy pasta water before draining.
Prepare the chicken:
Pat the chicken breasts dry with a paper towel and rub them all over with Cajun seasoning, pressing it into the surface so it really sticks. This step matters more than you'd think because dry chicken sears better and wet chicken just steams.
Sear the chicken:
Heat olive oil in a large skillet over medium-high until it shimmers, then lay the chicken in gently and let it cook undisturbed for five to six minutes per side until golden and cooked through. Let it rest a few minutes before slicing so the juices don't run out all over your cutting board.
Make the Alfredo sauce:
In the same skillet, melt butter over medium heat and add the minced garlic, stirring constantly for about thirty seconds until it smells incredible but hasn't browned. Pour in the heavy cream and whisk it gently, letting it come to a simmer without letting it boil over.
Thicken the sauce:
Stir in the Parmesan, black pepper, salt, and red pepper flakes, whisking until the cheese melts and the sauce thickens enough to coat the back of a spoon. If it gets too thick, add a tablespoon of pasta water at a time until it loosens up.
Combine everything:
Toss the cooked pasta into the skillet with the sauce, turning it with tongs until every strand is coated. Add the sliced Cajun chicken on top and toss once more so the spice and cream mix together.
Serve:
Plate it immediately while it's still steaming, then sprinkle chopped parsley and extra Parmesan over the top. This dish waits for no one.
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Tender slices of Cajun Chicken Alfredo tossed with silky Alfredo sauce, ready to be served with a glass of white wine. Save
Tender slices of Cajun Chicken Alfredo tossed with silky Alfredo sauce, ready to be served with a glass of white wine. | tastyhrira.com

One Sunday afternoon, I brought this to a potluck and watched a friend who claimed she didn't like spicy food go back for seconds. She said the cream tempered the heat just enough to make it exciting instead of painful, and I realized that's exactly what this dish does best. It walks that line between comfort and adventure, giving you the cozy feeling of Alfredo and the thrill of Cajun spice in every forkful. By the time I packed up to leave, the pan was empty and someone had already texted asking for the recipe.

How to Adjust the Heat

If you're nervous about spice, start with half the Cajun seasoning on the chicken and taste the sauce before adding red pepper flakes. You can always add more heat, but you can't take it away once it's in there. I've also learned that serving it with a side of garlic bread or a simple green salad helps balance the richness and gives your palate a break between bites. Some nights I make it mild for the kids and then shake extra Cajun seasoning on my own plate at the table, which keeps everyone happy without making two separate dinners.

Storage and Reheating

This keeps in the fridge for up to three days in an airtight container, and I've found the best way to reheat it is on the stovetop with a splash of milk or cream to loosen the sauce. The microwave works in a pinch, but the sauce can separate and get oily if you're not careful. I usually add a little extra Parmesan when reheating because it brings the flavors back to life and makes leftovers feel less like leftovers. It's one of those rare dishes that doesn't lose its appeal the second time around.

Variations Worth Trying

I've swapped the chicken for shrimp more than once, and it cooks even faster, which makes this a weeknight miracle. My friend who doesn't eat meat uses cubed tofu pressed dry and tossed in the Cajun seasoning, and it soaks up the sauce like a dream. Sometimes I throw in sautéed bell peppers or a handful of spinach just to add color and pretend I'm getting my vegetables in.

  • Try using penne or rigatoni if you want the sauce to get trapped inside the pasta for little pockets of flavor.
  • A squeeze of lemon juice at the very end brightens everything up and cuts through the richness in a surprising way.
  • If you want it even creamier, stir in a few tablespoons of cream cheese along with the Parmesan.
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Plated Cajun Chicken Alfredo with golden chicken strips, creamy sauce, and garnished with chopped parsley on a rustic wooden table. Save
Plated Cajun Chicken Alfredo with golden chicken strips, creamy sauce, and garnished with chopped parsley on a rustic wooden table. | tastyhrira.com

This dish has become my answer to the question of what to make when I want something impressive but don't have all day to cook. It's rich, it's bold, and it never fails to make dinner feel like an event worth sitting down for.

Recipe Questions & Answers

How do I prevent the Alfredo sauce from breaking?

Keep the heat at medium and avoid boiling the cream. Whisk constantly when adding the cream and use a gentle simmer. If the sauce becomes too thick, thin it with reserved pasta water rather than adding more cream.

Can I make this dish ahead of time?

Cook the chicken and sauce separately, then combine with freshly cooked pasta just before serving for best results. The sauce can be made up to 2 hours ahead and gently reheated.

What's the best way to cook the chicken so it stays tender?

Pat the chicken dry before seasoning, cook over medium-high heat for 5-6 minutes per side until it reaches 165°F internally, then let it rest for 2-3 minutes before slicing. This prevents drying out.

How can I adjust the spice level?

Control heat by reducing or increasing the Cajun seasoning on the chicken, or add red pepper flakes to the sauce. Taste as you go and adjust seasonings gradually for your preference.

What pasta works best for this dish?

Fettuccine and linguine are ideal because their flat, wide noodles catch and hold the creamy sauce well. Pappardelle or even penne work nicely as alternatives.

Can I substitute the cream with a lighter option?

Half-and-half or whole milk can reduce richness, though the sauce will be thinner. Use less cheese or add cornstarch slurry to maintain proper consistency with lighter dairy options.

Cajun Chicken Alfredo

Spicy Cajun chicken meets creamy Alfredo sauce in this vibrant Southern-Italian fusion pasta dish. Ready in under 40 minutes.

Prep time needed
15 minutes
Time to cook
25 minutes
Overall time
40 minutes
Recipe by Sophia Barnes

Recipe type Simple Comfort Foods

Skill level Medium

Cuisine type American Cajun-Italian Fusion

Total yield 4 Number of servings

Diet Preferences None specified

What you need

Chicken

01 2 large boneless, skinless chicken breasts
02 1 tablespoon Cajun seasoning
03 1 tablespoon olive oil

Pasta

01 12 ounces fettuccine or linguine pasta

Alfredo Sauce

01 2 tablespoons unsalted butter
02 3 cloves garlic, minced
03 1 1/2 cups heavy cream
04 1 cup freshly grated Parmesan cheese
05 1/4 teaspoon ground black pepper
06 1/4 teaspoon salt
07 1/4 teaspoon red pepper flakes

Garnish

01 2 tablespoons chopped fresh parsley
02 Extra grated Parmesan cheese for serving

How to make it

Step 01

Prepare the pasta: Bring a large pot of salted water to a boil. Add fettuccine and cook according to package directions until al dente. Reserve 1/2 cup pasta water and drain remainder. Set aside.

Step 02

Season the chicken: Pat chicken breasts dry and rub evenly with Cajun seasoning on all sides.

Step 03

Cook the chicken: Heat olive oil in a large skillet over medium-high heat. Add chicken breasts and cook 5-6 minutes per side until golden and internal temperature reaches 165°F. Remove from skillet, rest 2-3 minutes, then slice into strips.

Step 04

Create the Alfredo sauce: In the same skillet over medium heat, melt butter. Add minced garlic and sauté 30 seconds until fragrant. Pour in heavy cream while whisking constantly and bring to a gentle simmer without boiling.

Step 05

Finish the sauce: Stir in Parmesan cheese, black pepper, salt, and red pepper flakes. Simmer 2-3 minutes until sauce thickens. If too thick, add reserved pasta water one tablespoon at a time.

Step 06

Combine components: Add cooked pasta to the skillet and toss thoroughly to coat with Alfredo sauce. Add sliced Cajun chicken and toss again.

Step 07

Plate and serve: Divide onto serving plates immediately. Garnish with chopped parsley and extra Parmesan cheese.

Needed tools

  • Large pot
  • Large skillet
  • Tongs
  • Chef's knife
  • Cutting board
  • Measuring cups and spoons
  • Whisk

Allergy details

Always check every item for allergens. If unsure, please talk to a professional.
  • Contains milk: heavy cream, butter, Parmesan cheese
  • Contains wheat: pasta
  • May contain eggs if using fresh pasta
  • Verify Cajun seasoning ingredient label for gluten and other allergens

Nutrition details (each serving)

Nutritional data here is just for general reference. It shouldn't replace health advice.
  • Caloric value: 670
  • Fat content: 34 grams
  • Carbohydrates: 54 grams
  • Proteins: 40 grams